ASA 125th Meeting Ottawa 1993 May

3pPA1. Ultrasound enhanced generation of hydroxyl radicals from anticancer drugs: Adramycin and Mitomycin C.

Darayash Tata

Tom R. Tritton

Dept. of Pharmacology, Univ. of Vermont, Burlington, VT 05405

Junru Wu

Univ. of Vermont, Burlington, VT 05405

It has been reported that OH production in anticancer drug Adramycin and Mitomycin C suspensions is dramatically enhanced by applying 0.5-MHz cw ultrasound (US). Time course studies were performed to characterize the OH generation with and without US exposures. The results show that to a first approximation [OH] can be expressed as superposition of a rapid exponentially growing term and a slow linear varying term. The experiment indicated that the first term is due to US. In view of these observations it is concluded that US activated some shortly lived OH generating pathways.