Tom R. Tritton
Dept. of Pharmacology, Univ. of Vermont, Burlington, VT 05405
Univ. of Vermont, Burlington, VT 05405
It has been reported that OH production in anticancer drug Adramycin and Mitomycin C suspensions is dramatically enhanced by applying 0.5-MHz cw ultrasound (US). Time course studies were performed to characterize the OH generation with and without US exposures. The results show that to a first approximation [OH] can be expressed as superposition of a rapid exponentially growing term and a slow linear varying term. The experiment indicated that the first term is due to US. In view of these observations it is concluded that US activated some shortly lived OH generating pathways.