Re: Auditory efferents and phase locking

[José Ignacio Alcántara <jia10@xxxxxxxxx>]

On Sep 1 2011, Matt Flax wrote:

If you accept that some or many of the ageing/senescence effects are due to 
mitochondrial dysfunction*, then you might expect those (sensory) neurones 
with the highest energy demands to be particularly vulnerable: presbyacusis 
might simply be the result of OHC/IHC/AN damage/apoptosis?

*e.g., Oxidative damage during aging targets mitochondrial aconitase
LIANG-JUN YAN, RODNEY L. LEVINE, AND RAJINDAR S. SOHAL
Proc. Natl. Acad. Sci. USA
Vol. 94, pp. 11168-11172, October 1997

Jose


> p.s. If it was to protect, then why is Presbycusis so bad ?

> On Wed, 2011-08-31 at 16:54 -0700, Richard F. Lyon wrote:
> > Perhaps the 
> > gain-control role is primarily protective, as many have speculated? 

--
José
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José Ignacio Alcántara, PhD
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