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Re: Auditory efferents and phase locking
On Sep 1 2011, Matt Flax wrote:
If you accept that some or many of the ageing/senescence effects are due to
mitochondrial dysfunction*, then you might expect those (sensory) neurones
with the highest energy demands to be particularly vulnerable: presbyacusis
might simply be the result of OHC/IHC/AN damage/apoptosis?
*e.g., Oxidative damage during aging targets mitochondrial aconitase
LIANG-JUN YAN, RODNEY L. LEVINE, AND RAJINDAR S. SOHAL
Proc. Natl. Acad. Sci. USA
Vol. 94, pp. 11168-11172, October 1997
p.s. If it was to protect, then why is Presbycusis so bad ?
On Wed, 2011-08-31 at 16:54 -0700, Richard F. Lyon wrote:
gain-control role is primarily protective, as many have speculated?
José Ignacio Alcántara, PhD
Department of Experimental Psychology
University of Cambridge
Cambridge CB2 3EB
Tel: +44 (0)1223 764412
Fellow of Fitzwilliam College
Cambridge CB3 0DG
Tel: +44 (0)1223 472126