AW: Cochlear Maps ("reinifrosch@xxxxxxxx" )


Subject: AW: Cochlear Maps
From:    "reinifrosch@xxxxxxxx"  <reinifrosch@xxxxxxxx>
Date:    Tue, 26 Sep 2006 10:32:08 +0000

Dear Donald and List, Although Fig. 11-39 of von Békésy's book "Experiments in Hearing" (1960) was drawn long before the discovery of active amplification in outer hair cells (1985), it implies that, for a given sine-tone frequency in the range from 100 to 1000 Hz, the x-coordinate given by the "active" map ("localization from hearing loss measurements") is greater (i.e., farther from the stapes) than that of the "passive" map by 4 or 5 mm. At low and high frequencies, the differences x(active) - x(passive) appear to be smaller, so that in a plot of log(f) versus x the shapes of the two curves differ. At the "active" peak, the cochlear wave is still travelling; at a given sine-tone frequency of a few kHz, the "resonance" location is therefore even more apical than the "active" one, by typically 2 mm in humans. I have to admit, however, that I do not know whether von Békésy's data have been contradicted by later ones. Reinhart Frosch. Reinhart Frosch, Dr. phil. nat., r. PSI and ETH Zurich, Sommerhaldenstr. 5B, CH-5200 Brugg. Phone: 0041 56 441 77 72. Mobile: 0041 79 754 30 32. E-mail: reinifrosch@xxxxxxxx . ----Ursprüngliche Nachricht---- Von: ddg@xxxxxxxx Datum: 25.09.2006 19:32 An: <AUDITORY@xxxxxxxx> Betreff: Cochlear Maps Dear Dr. Reinhart Frosch and List, [...] In whatever way my 1961,1990 empirical-descriptive curve is now to be categorized, the frequency-place data summarized in my 1990 paper cannot be so neatly divided into (a) data from dead humans and (b) in vivo data obtained at only high (> 100 dB SPL) levels in the various other species considered. [...] Of course, Bekesy's data are from dead cochleas, and were also obtained at very high signal levels, so that "passive" or "passive-mode" data may be an appropriate way to describe them. Not so for most of the in vivo data, mis-characterized above as having been obtained at very hign signal levels. Much of the in vivo frequency-place data in other species summarized in 1990 were not obtained using tones greater than 100 dB, quite notably not in the case of Liberman's (1982) very full set of data (or Kohlloffel's basal data - 1974,75) in the cat, where single unit CF determinations (i.e. near-threshold measurements) were related to fiber place of origin along the cochlea. In addition, Muller's Mongolian gerbil data [(1996) in Hear Res, 94, 148-196] were obtained in the same way as Liberman's. CFs determined at tuning curve tips uniformly measured at signal levels over 100 dB SPL? In the guinea pig probably the mechanical data (i.e. Wilson and Johnstone's) were obtained at fairly high signal levels (and from cochleas in an altered condition), so call them "passive", but not, I think, Dallos' data (using CM). Moreover, as for the other GP data, we are back to CFs: Russell and Sellick (inner haircell CFs), or Robertson and Manley (spiral ganglion cell CFs). Data from the chinchilla (Eldredge, CID data) and data of Stebbins and Moody (1979- 88), relating to a species of old-world monkey, related place of cochlear lesion to cut-off frequencies (a threshold curve "shoulder" related to place of loss) and hence were obtained differently than in the experiments above, but not at particularly high levels. It needs to be recognized by list members not working on cochlear issues that most of the in vivo data collated in the 1990 paper cannot be characterized correctly as obtained only, or even largely, at very high signal levels, but rather the reverse. Most actually would fall in the "Active-mode" data category. Does that raise a problem? Curves of identical form appear to describe data obtained at much lesser signal intensity levels than 100 dB SPL. The curve is still empirical: one parameter (exponential coefficient) can remain identical, a second nearly so, with only the third varying to accommodate different frequency ranges. But is the curve now "active", having been "passive" in respect to dead human data (and the one "passive" set of GP data)?. The same curve form would seem oddly categorized if called both "passive" (when applied to dead humans and Keele guinea pigs) and "active" (when applied to EPL cats and Sussex and Evanston guinea pigs), i.e. depending just on the data or conditions applied to. Perhaps, better apply the terms at this point only to data sets themselves, depending on stimulus level used or cochlear physical condition. But, it also seems that some data sets obtained at high signal levels in the Keele guinea pigs appeared to agree with other data sets obtained at low signal levels in other guinea pigs - an oddness noted in a 1990 footnote. If that agreement were valid, what do the terms "passive" and "active" mean in that context? This is not to deny importance to efforts to use such terms and address these issues; it is only perhaps to illustrate that a theoretician's lot may not be a happy one if the data cupboard is opened. Some data may be hard to reconcile with others - or with theoretical positions. I hope this "clarification" of the in vivo data reviewed in 1990 will be helpful - in trying to redirect attention to the methods used and actual conditions under which each type of such data (in the field, not just in that paper) have been obtained, however discouraging that may be on occasion. Cheers, Donald D. Greenwood


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