Re: [AUDITORY] Unanesthetized measurements (Bob Carlyon )

Subject: Re: [AUDITORY] Unanesthetized measurements From: Bob Carlyon <Bob.Carlyon@xxxxxxxx> Date: Mon, 16 Sep 2013 14:42:07 +0000 List-Archive:<http://lists.mcgill.ca/scripts/wa.exe?LIST=AUDITORY> --_004_9A9432BC31857848B97F53CEAE8386C48195009BWSR22mrccbsuloc_ Content-Type: multipart/alternative; boundary="_000_9A9432BC31857848B97F53CEAE8386C48195009BWSR22mrccbsuloc_" --_000_9A9432BC31857848B97F53CEAE8386C48195009BWSR22mrccbsuloc_ Content-Type: text/plain; charset="us-ascii" Content-Transfer-Encoding: quoted-printable You may be interested in some measurements obtained by Brad May and Murray = Sachs to VCN units in awake behaving cats. The response properties of thes= e units in anaesthetised animals are similar to those of the AN, so this ma= y be as close as you'll get to how the AN might respond in the awake animal= : DYNAMIC-RANGE OF NEURAL RATE RESPONSES IN THE VENTRAL COCHLEAR NUCLEUS OF A= WAKE CATS Author(s): MAY, BJ<http://apps.webofknowledge.com/OneClickSearch.do?product= =3DUA&search_mode=3DOneClickSearch&colName=3DWOS&SID=3DS2atHEzQsjD4JpRQ8lw&= field=3DAU&value=3DMAY,%20BJ&ut=3D1935206&pos=3D%7B2%7D&excludeEventConfig= =3DExcludeIfFromFullRecPage> (MAY, BJ); SACHS, MB<http://apps.webofknowledg= e.com/OneClickSearch.do?product=3DUA&search_mode=3DOneClickSearch&colName= =3DWOS&SID=3DS2atHEzQsjD4JpRQ8lw&field=3DAU&value=3DSACHS,%20MB&ut=3D845556= 2&pos=3D%7B2%7D&excludeEventConfig=3DExcludeIfFromFullRecPage> (SACHS, MB) Source: JOURNAL OF NEUROPHYSIOLOGY Volume: 68 Issue: 5 Pages: 1589-160= 2 Published: NOV 1992 Times Cited: 37<http://apps.webofknowledge.com/CitingArticles.do?product=3D= UA&search_mode=3DCitingArticles&SID=3DS2atHEzQsjD4JpRQ8lw&parentProduct=3DU= A&parentQid=3D1&excludeEventConfig=3DExcludeIfFromFullRecPage&parentDoc=3D1= &REFID=3D18488170&recordId=3DWOS:A1992JY68500009&alldbColName=3DWOS&colName= =3DWOS> (from Web of Science) Cited References: 41<http://apps.webofknowledge.com/CitedRefList.do?product= =3DUA&search_mode=3DCitedRefList&SID=3DS2atHEzQsjD4JpRQ8lw&colName=3DWOS&pa= rentProduct=3DUA&parentQid=3D1&parentDoc=3D1&recid=3DWOS:A1992JY68500009&UT= =3DWOS:A1992JY68500009&excludeEventConfig=3DExcludeIfFromFullRecPage&sortBy= =3DPY.D&recordId=3DWOS:A1992JY68500009> [ view related records<http://= apps.webofknowledge.com/Related.do?UT=3DWOS:A1992JY68500009&refColName=3DFA= STRDB&parentProduct=3DUA&parentQid=3D1&product=3DUA&search_mode=3DRelatedRe= cords&SID=3DS2atHEzQsjD4JpRQ8lw&colName=3DWOS&parentDoc=3D1&excludeEventCon= fig=3DExcludeIfFromFullRecPage&recordId=3DWOS:A1992JY68500009> ] [Citat= ion Map] Citation Map<javascript:;> Abstract: 1. Response thresholds and dynamic range properties of neurons in= the ventral cochlear nucleus (VCN) of awake cats were measured by fitting = a computational model to rate-level functions for best frequency (BF) tone = bursts and for bursts of broad-band noise. Dynamic range measurements were = performed in quiet and in the presence of continuous background noise. 2. The sample of neurons obtained in the VCN of awake cats exhibited a vari= ety of peristimulus histograms (PSTHs) and thresholds. All PSTH response ty= pes previously described in the VCN of anesthetized cats were found in awak= e cats. The lowest thresholds for neural responses were observed at sound p= ressure levels that were equivalent to behavioral thresholds of absolute au= ditory sensitivity. 3. When responses to BF tones or bursts of broad-band noise were recorded i= n quiet backgrounds, the dynamic range properties of most units in the VCN = of awake cats were not significantly different from dynamic range propertie= s of auditory nerve fibers (ANFs) in anesthetized cats or VCN units in dece= rebrate cats. All auditory units showed a larger dynamic range for noise bu= rsts than for tone bursts, but VCN units with primary-like and onset PSTHs = showed larger dynamic ranges for responses to noise bursts than that of ANF= s and VCN chopper units. 4. When tests were performed in the presence of continuous noise, rate-leve= l functions for BF tone bursts shifted to higher tone levels and showed a m= ore compressed range of driven rates in comparison with data obtained in qu= iet. Compression of the rate-level function in noise resulted from an incre= ase in driven rate at low tone levels and a decrease in rate at high tone l= evels. These changes in the rate-level function suggest that noise may redu= ce the range of BF tone levels that are potentially encoded by a unit's rat= e responses. By exhibiting larger shifts and less compression in background= noise, VCN units in awake cats better preserved the dynamic range of their= rate responses to BF tones than ANFs in anesthetized cats or VCN units in = decerebrate cats. 5. Rate-level functions were obtained from a small sample of VCN units not = only with the cat performing the behavioral task but also with the cat awak= e and sitting quietly in the testing apparatus. No differences in noise-ind= uced shift or compression were noted between the two testing conditions. 6. The dynamic range adjustments to noise exhibited by VCN units in awake c= ats are similar to changes in the rate responses of ANFs that are elicited = in anesthetized cats by electrical stimulation of the crossed olivocochlear= bundle. Dr. Bob Carlyon Programme Leader MRC Cognition & Brain Sciences Unit 15 Chaucer Rd. Cambridge CB2 7EF England Tel: +44 (0)1223 355294 Fax: +44 (0)1223 355294 www.mrc-cbu.cam.ac.uk<http://www.mrc-cbu.cam.ac.uk/> MRC Centenary 1913-2013 | 100 years of life-changing discoveries From: AUDITORY - Research in Auditory Perception [mailto:AUDITORY@xxxxxxxx= ILL.CA] On Behalf Of Derek Burton Sent: 13 September 2013 07:27 To: AUDITORY@xxxxxxxx Subject: Unanesthetized measurements Dear List, Has anyone made auditory nerve and/or basilar membrane motion measurements = in awake, behaving (non-decerebrate) animals? Thanks for any input, Derek Burton dB, PhD --_000_9A9432BC31857848B97F53CEAE8386C48195009BWSR22mrccbsuloc_ Content-Type: text/html; charset="us-ascii" Content-Transfer-Encoding: quoted-printable <html xmlns:v=3D"urn:schemas-microsoft-com:vml" xmlns:o=3D"urn:schemas-micr= osoft-com:office:office" xmlns:w=3D"urn:schemas-microsoft-com:office:word" = xmlns:m=3D"http://schemas.microsoft.com/office/2004/12/omml" xmlns=3D"http:= //www.w3.org/TR/REC-html40"> <head> <meta http-equiv=3D"Content-Type" content=3D"text/html; charset=3Dus-ascii"= > <meta name=3D"Generator" content=3D"Microsoft Word 14 (filtered medium)"> <style></style> </head> <body lang=3D"EN-GB" link=3D"blue" vlink=3D"purple"> <div class=3D"WordSection1"> You may be interested in = some measurements obtained by Brad May and Murray Sachs to VCN units in awa= ke behaving cats. The response properties  of these units in anaesthetised animals are similar to those of the AN, so this may be as= close as you’ll get to how the AN might respond in the awake animal:= <o:p></o:p> <o:p> </o:p><= /p> <table class=3D"MsoNormalTable" border=3D"0" cellspacing=3D"0" cellpadding= =3D"0"> <tbody> <tr> <td style=3D"padding:0cm 0cm 0cm 0cm"> DYNAMIC-RANGE OF NEURAL RATE RESPONSES IN THE VENTRA= L COCHLEAR NUCLEUS OF AWAKE CATS <o:p></o:p> </td> </tr> <tr> <td style=3D"padding:0cm 0cm 0cm 0cm"> Author(s): <a href=3D= "http://apps.webofknowledge.com/OneClickSearch.do?product=3DUA&search_m= ode=3DOneClickSearch&colName=3DWOS&SID=3DS2atHEzQsjD4JpRQ8lw&fi= eld=3DAU&value=3DMAY,%20BJ&ut=3D1935206&pos=3D%7B2%7D&exclu= deEventConfig=3DExcludeIfFromFullRecPage" title=3D"Find more records by thi= s author"> M= AY, BJ</a> (MAY, BJ); <a href=3D"http://apps.webofknowledge.com/OneClickSearch.do?product=3DUA&am= p;search_mode=3DOneClickSearch&colName=3DWOS&SID=3DS2atHEzQsjD4JpRQ= 8lw&field=3DAU&value=3DSACHS,%20MB&ut=3D8455562&pos=3D%7B2%= 7D&excludeEventConfig=3DExcludeIfFromFullRecPage" title=3D"Find more re= cords by this author"> S= ACHS, MB</a> (SACHS, MB) <o:p></o:p> </td> </tr> <tr> <td style=3D"padding:0cm 0cm 0cm 0cm"> Source: JOURNAL OF NE= UROPHYSIOLOGY  Volume: 68  &n= bsp;Issue: 5   Pages: 1589-1602   Published:= NOV 1992 <o:p></o:p> </td> </tr> <tr> <td style=3D"padding:0cm 0cm 0cm 0cm"> Times Cited: <a href= =3D"http://apps.webofknowledge.com/CitingArticles.do?product=3DUA&searc= h_mode=3DCitingArticles&SID=3DS2atHEzQsjD4JpRQ8lw&parentProduct=3DU= A&parentQid=3D1&excludeEventConfig=3DExcludeIfFromFullRecPage&p= arentDoc=3D1&REFID=3D18488170&recordId=3DWOS:A1992JY68500009&al= ldbColName=3DWOS&colName=3DWOS" title=3D"View all of the articles that = cite this one"> 37</a> (from Web of Science) <o:p></o:p> </td> </tr> <tr> <td style=3D"padding:0cm 0cm 0cm 0cm"> Cited References: <a = href=3D"http://apps.webofknowledge.com/CitedRefList.do?product=3DUA&sea= rch_mode=3DCitedRefList&SID=3DS2atHEzQsjD4JpRQ8lw&colName=3DWOS&amp= ;parentProduct=3DUA&parentQid=3D1&parentDoc=3D1&recid=3DWOS:A19= 92JY68500009&UT=3DWOS:A1992JY68500009&excludeEventConfig=3DExcludeI= fFromFullRecPage&sortBy=3DPY.D&recordId=3DWOS:A1992JY68500009" titl= e=3D"View this record's bibliography"> 41</a>      [ <a hr= ef=3D"http://apps.webofknowledge.com/Related.do?UT=3DWOS:A1992JY68500009&am= p;refColName=3DFASTRDB&parentProduct=3DUA&parentQid=3D1&product= =3DUA&search_mode=3DRelatedRecords&SID=3DS2atHEzQsjD4JpRQ8lw&co= lName=3DWOS&parentDoc=3D1&excludeEventConfig=3DExcludeIfFromFullRec= Page&recordId=3DWOS:A1992JY68500009" title=3D"View other records that s= hare references with this one">view related records</a> ]     <a href=3D"javascript:;" title=3D"View the Citation Map"><img border=3D"0" width=3D"18" height= =3D"12" id=3D"Picture_x0020_1" src=3D"cid:image001.gif@xxxxxxxx" a= lt=3D"Citation Map">Citation Map</a>     <o:p></o:p></p= > </td> </tr> <tr> <td style=3D"padding:0cm 0cm 0cm 0cm"> Abstract: 1. Response= thresholds and dynamic range properties of neurons in the ventral cochlear= nucleus (VCN) of awake cats were measured by fitting a comp= utational model to rate-level functions for best frequency (BF) tone bursts= and for bursts of broad-band noise. Dynamic range measurements were perfor= med in quiet and in the presence of continuous background noise. 2. The sample of neurons obtained in the VCN of a= wake cats exhibited a variety of peristimulus histograms (PSTHs) and= thresholds. All PSTH response types previously described in the VCN of ane= sthetized cats were found in awake cats. The lowest thresholds for neur= al responses were observed at sound pressure levels that were equivalent to= behavioral thresholds of absolute auditory sensitivity. 3. When responses to BF tones or bursts of broad-band noise were recorded i= n quiet backgrounds, the dynamic range properties of most units in the VCN = of awake cats were not significantly differen= t from dynamic range properties of auditory nerve fibers (ANFs) in anesthet= ized cats or VCN units in decerebrate cats. All auditory units showed a lar= ger dynamic range for noise bursts than for tone bursts, but VCN units with primary-like and onset PSTHs show= ed larger dynamic ranges for responses to noise bursts than that of ANFs an= d VCN chopper units. 4. When tests were performed in the presence of continuous noise, rate-leve= l functions for BF tone bursts shifted to higher tone levels and showed a m= ore compressed range of driven rates in comparison with data obtained in qu= iet. Compression of the rate-level function in noise resulted from an increase in driven rate at low tone lev= els and a decrease in rate at high tone levels. These changes in the rate-l= evel function suggest that noise may reduce the range of BF tone levels tha= t are potentially encoded by a unit's rate responses. By exhibiting larger shifts and less compression in backgr= ound noise, VCN units in awake cats better preserved the dynamic ra= nge of their rate responses to BF tones than ANFs in anesthetized cats or V= CN units in decerebrate cats. 5. Rate-level functions were obtained from a small sample of VCN units not = only with the cat performing the behavioral task but also with the cat awake and sitting quietly in the testing a= pparatus. No differences in noise-induced shift or compression were noted b= etween the two testing conditions. 6. The dynamic range adjustments to noise exhibited by VCN units in awake cats are similar to changes in the rate responses of ANFs that= are elicited in anesthetized cats by electrical stimulation of the crossed= olivocochlear bundle. <o:p></o:p> </td> </tr> </tbody> </table>  <o:p></o:p><= /p> <o:p> </o:p><= /p> Dr. Bob Carlyon<o:p></o:p= > Programme Leader<o:p></o:= p> MRC Cognition & Brain= Sciences Unit<o:p></o:p> 15 Chaucer Rd.<o:p></o:p>= Cambridge CB2 7EF<o:p></o= :p> England<o:p></o:p>= Tel: +44 (0)1223 3552= 94<o:p></o:p> Fax: +44 (0)1223 3552= 94<o:p></o:p> <a href=3D"http://www.mrc= -cbu.cam.ac.uk/">www.mrc-cbu.cam.ac.uk</a><o:p></o:p> <o:p> </o:p><= /p> MRC Centenary 1913-2013= | 100 years of life-changing discoveries<o:p></o:p> <o:p> </o:p><= /p> <o:p> </o:p><= /p> From: AUDITORY - Research in Auditory Perception [mailto:AU= DITORY@xxxxxxxx On Behalf Of Derek Burton Sent: 13 September 2013 07:27 To: AUDITORY@xxxxxxxx Subject: Unanesthetized measurements<o:p></o:p> <o:p> </o:p> <div> <div> Dear List,<o:p></o:p>= </div> <div> Has anyone made audit= ory nerve and/or basilar membrane motion measurements in awake, behaving (n= on-decerebrate) animals?<o:p></o:p> </div> <div> Thanks for any input, Derek Burton<o:p></o:p> </div> <div> dB, PhD<o:p></o:p></p= > </div> </div> </div> </body> </html> --_000_9A9432BC31857848B97F53CEAE8386C48195009BWSR22mrccbsuloc_-- --_004_9A9432BC31857848B97F53CEAE8386C48195009BWSR22mrccbsuloc_ Content-Type: image/gif; name="image001.gif" Content-Description: image001.gif Content-Disposition: inline; filename="image001.gif"; size=208; creation-date="Mon, 16 Sep 2013 14:42:07 GMT"; modification-date="Mon, 16 Sep 2013 14:42:07 GMT" Content-ID: <image001.gif@xxxxxxxx> Content-Transfer-Encoding: base64 R0lGODlhEgAMAMQAAP///+zs7Ovr6+rq6ufn5+bm5tzc3Nvb29fX18vLy8nJyb+/v7i4uLW1tbKy sq6urqysrJmZmWdnZ2ZmZgAA/////wAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAACH5BAEH ABUALAAAAAASAAwAAAVN4CSNZGmSQKquLDCmUdzGUfoCVF6ohZBTNsmqwAgAAozd6kU7OCK5R4JA cwl/C0Mgh1A0flYWMYBUqm40gbIAqYZxOdYA/G7Zrad8KQQAOw== --_004_9A9432BC31857848B97F53CEAE8386C48195009BWSR22mrccbsuloc_--

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