[Date Prev][Date Next][Thread Prev][Thread Next][Date Index][Thread Index]
Re: triggers for neural activity in the auditory periphery
Title: Re: triggers for neural activity in the auditory
There are at least two "levels" at which one can
consider your question. One level is that of discrete auditory
events, e.g., the onset of some stimulus.
Peter Heil and Dexter Irvine have published a very nice program
of work, in anesthetized cats and using tonal stimuli, which showed
the importance of rate of change of pressure (at least for linear
rise-time stimuli) in determining both response amplitude and response
latency at the auditory nerve and in more central structures.
I've pasted the references to some of this work below.
Bob Burkard's group and mine have confirmed some of the foregoing
findings in unanesthetized animals and using noise stimuli.
References to some of that work are also pasted below. The 2002
review article provides a broader context for this line of
The second level is that of the individual cycles of an ongoing
tonal (or other) stimulus, as in the case of phase-locking. In
that instance, motion of the cochlear partition towards scala
vestibuli contributes significantly to the excitatory phase of the
transduction process. Some of this work is reviewed by Ruggero
(1992, reference below).
I hope that this helps. All good wishes,
Heil, P. (1997a) Auditory onset
responses revisted. I. First-spike timing. J.
Neurophysiol., 77: 2616-2641.
Heil, P. (1997b) Auditory onset responses revisted.
II. Response strength. J. Neurophysiol., 77:
Heil, P. and Irvine, D.R.F. (1997) First-spike timing of
auditory-nerve fibers and comparison with auditory cortex. J.
Neurophysiol., 78: 2438-2454.
Phillips, D.P., Hall, S.E., Guo, Y-Q and
Burkard, R. (2001) Sensitivity of unanesthetized
chinchilla auditory system to noise burst onset, and the effects of
carboplatin. Hearing Res., 155: 133-142.
Phillips, D.P., Hall, S.E. and Boehnke, S.E. (2002)
Central auditory onset responses, and temporal asymmetries in auditory
perception. Hearing Res., 167: 192-205.
Ruggero, M.A. (1992) Physiology
and coding of sound in the auditory nerve. In: A.N. Popper and R.R.
Fay (Eds.), The Mammalian Auditory Pathway: Neurophysiology. New
York: Springer-Verlag, pp34-93.
any physiological studies on the question, what are the exact triggers
for the activation of auditory brainstem nuclei? I am especially
interested in the question whether the CN responds to abrupt peaks in
the activity of the auditory nerve, or rather exhibits temporal
integration characteristics before becoming active itself. Is there
any knowledge about the order of such integration times and are they