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Re: two-tone suppression

Cochlear mechanical nonlinearity is most likely the result of saturation
in the outer hair cell mechanical to electrical transduction process.
See for example:

Mountain DC, Hubbard AE. A piezoelectric model of outer
hair cell function.  J Acoust Soc Am. 1994 Jan;95(1):350-4.

For more info on 2TS and BM mechanics, see the following papers and their

Rhode WS, Recio A.  Multicomponent stimulus interactions observed in
basilar-membrane vibration in the basal region of the chinchilla cochlea.
J Acoust Soc Am. 2001 Dec;110(6):3140-54.

Robles L, Ruggero MA. Mechanics of the mammalian cochlea. Physiol Rev.
2001 Jul;81(3):1305-52.


David C. Mountain, Ph.D.
Professor of Biomedical Engineering

Boston University
44 Cummington St.
Boston, MA 02215

Email:   dcm@xxxxxx
Website: http://earlab.bu.edu/external/dcm/
Phone:   (617) 353-4343
FAX:     (617) 353-6766
Office:  ERB 413
On Wed, 21 Sep 2005, Ben Lineton wrote:

> Two-tone suppression can also arise from cochlear nonlinearity, as evidenced by mechanical measurements of basilar membrane 2TS (sorry I can't remember the reference), and by measurements of 2TS in otoacoustic emissions (e.g. Brass and Kemp, Suppression of stimulus frequency otoacoustic emissions, J Acoust Soc Am. 1993 Feb;93(2):920-39).
> Put simply, the suppressor tone drives the cochlear amplifier into saturation, so that its response to the probe tone is reduced.
> Ben
> >>> Martin Braun <nombraun@xxxxxxxxx> 21/09/2005 14:47 >>>
> Monita Chatterjee asked:
> > What is the latest on an explanation/model for two-tone suppression?
> These papers may be of use:
> Webster, W.R., Servieére, J., Martin, R., Brown, M., 1985. Uncrossed
> and crossed inhibition in the inferior colliculus of the cat: A combined
> 2-deoxyglucose and electrophysiological study. J. Neurosci. 5, 1820-1832.
> Palombi, P.S., Caspary, D.M., 1996. GABA inputs control discharge
> rate primarily within frequency receptive fields of inferior colliculus
> neurons. J. Neurophysiol. 75, 2211-2219.
> Caspary, D.M., Helfert, R.H., Palombi, P.S., 1997. The role of
> GABA in shaping frequency response properties in the chinchilla
> inferior colliculus. In: Syka, J. (Ed.), Acoustic Signal Processing in
> the Central Auditory System. Plenum Press, New York, pp. 227-238.
> Martin
> ----------------------------
> Martin Braun
> Neuroscience of Music
> S-671 95 Klässbol
> Sweden
> web site: http://w1.570.telia.com/~u57011259/index.htm